Article
The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid development.
Proceedings of the National Academy of Sciences of the United States of America - 27 Dec 2016
Lemonnier François, Cairns Rob A, Inoue Satoshi, Li Wanda Y, Dupuy Aurélie, Broutin Sophie, Martin Nadine, Fataccioli Virginie, Pelletier Romain, Wakeham Andrew, Snow Bryan E, de Leval Laurence, Pujals Anais, Haioun Corinne, Paci Angelo, Tobin Erica R, Narayanaswamy Rohini, Yen Katherine, Jin Shengfang, Gaulard Philippe, Mak Tak W
Abstract excerpt
Oncogenic isocitrate dehydrogenase (IDH)1 and IDH2 mutations at three hotspot arginine residues cause an enzymatic gain of function that leads to the production and accumulation of the metabolite 2-hydroxyglutarate (2HG), which contributes to the development of a number of malignancies. In the hematopoietic system, mutations in IDH1 at arginine (R) 132 and in IDH2 at R140 and R172 are commonly observed in acute...
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