Multiple Ways to Detect IDH2 Mutations in Angioimmunoblastic T-Cell Lymphoma from Immunohistochemistry to Next-Generation Sequencing.

doi:10.1016/j.jmoldx.2018.05.012

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Article

Multiple Ways to Detect IDH2 Mutations in Angioimmunoblastic T-Cell Lymphoma from Immunohistochemistry to Next-Generation Sequencing.

The Journal of molecular diagnostics : JMD - 1 Sept 2018

Dupuy Aurélie, Lemonnier François, Fataccioli Virginie, Martin-Garcia Nadine, Robe Cyrielle, Pelletier Romain, Poullot Elsa, Moktefi Anissa, Mokhtari Karima, Rousselet Marie C, Traverse-Glehen Alexandra, Delarue Richard, Tournilhac Olivier, Delfau-Larue Marie H, Haioun Corinne, Ortonne Nicolas, Copie-Bergman Christiane, de Leval Laurence, Pujals Anaïs, Gaulard Philippe

Abstract excerpt

Angioimmunoblastic T-cell lymphoma (AITL) is a peripheral T-cell lymphoma associated with chemoresistance and a poor prognosis. Various nonsynonymous mutations in the R172 residue of IDH2 are present in 20% to 30% of AITL patients. In addition to their diagnostic value, these mutations are potentially targetable, especially by isocitrate dehydrogenase (IDH) 2 inhibitor, and therefore their identification in a...

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Identifiers

PMID: 29981867
DOI: 10.1016/j.jmoldx.2018.05.012

Genes

IDH2

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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