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Integrated analysis of UGT1A1 promoter polymorphism, gene expression, and IL-1β reveals genotype-driven susceptibility in Gilbert syndrome.

Molecular biology reports - 30 Jun 2026

Hussein Sahar M, Al-Haddad Roya Hadi, Shareef Saja Ali, Abdallah Mays Talib

Abstract excerpt

BACKGROUND: Gilbert syndrome (GS) is an inherited disorder characterized by unconjugated hyperbilirubinemia as a result of the reduced transcriptional activity of proteins of UGT1A1. The roles and mechanisms of promoter polymorphism, gene expression, and inflammation are not fully understood, particularly in Middle Eastern populations, including Iraq. METHODS: A case-control study with 50 GS patients and 50...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42377777
DOI: 10.1007/s11033-026-12261-4

Genes

UGT1A1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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