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Gilbert Syndrome: The <i>UGT1A1</i> *28 Promoter Polymorphism as a Biomarker of Multifactorial Diseases and Drug Metabolism

26 Mar 2012

Abstract excerpt

Gilbert syndrome belongs to the group of the most common human metabolic disorders and is characterized by an elevated level of bilirubin in blood serum. A polymorphism of the 5´ end of the UGT1A1 gene promoter, a homozygous insertion of TA pairs (genotype UGT1A1*28/*28), results in a decrease in bilirubin glucuronidation activity and therefore leads to an increase in the level of unconjugated bilirubin...

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Identifiers

PMID: 22448797
DOI: 10.2217/bmm.12.4

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