Article
Stochastic processes in the aetiopathogenesis of scleroderma.
Internal medicine journal - 1 Mar 2012
Roberts-Thomson P J, Walker J G
Abstract excerpt
We review the aetiology of scleroderma from an epidemiological perspective examining genetic, environmental and stochastic risk factors. The presence of familial clustering (but with low twin concordance) suggests a genetic contribution, and this has been confirmed with recent candidate gene and genome-wide association screening demonstrating both major histocompatibility complex and non-major histocompatibility...
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