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Article

Familial and genetic overlap between Sjögren's disease and other autoimmune diseases.

Frontiers in immunology - 1 Jan 2026

Ono-Minagi Hitomi, Ohnishi Takuma, Atyeo Natalie, Okuno Kentaro, Burbelo Peter D, Chiorini John A

Abstract excerpt

Purpose: To evaluate familial clustering of Sjögren's disease (SjD) with other autoimmune diseases and to characterize shared genetic architecture using an integrative genomic approach. Methods: Meta-analysis identified studies assessing autoimmune disease incidence in probands and first-degree relatives (FDRs), and pooled relative risks (RRs) were calculated. Publicly available genome-wide association study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41972126
DOI: 10.3389/fimmu.2026.1740360
PMCID: PMC13062241

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