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Article

Tamoxifen induces cellular stress in the nervous system by inhibiting cholesterol synthesis.

Acta neuropathologica communications - 26 Nov 2015

Denk Franziska, Ramer Leanne M, Erskine Erin L K S, Nassar Mohammed A, Bogdanov Yury, Signore Massimo, Wood John N, McMahon Stephen B, Ramer Matt S

Abstract excerpt

BACKGROUND: Tamoxifen (TAM) is an important cancer therapeutic and an experimental tool for effecting genetic recombination using the inducible Cre-Lox technique. Despite its widespread use in the clinic and laboratory, we know little about its effects on the nervous system. This is of significant concern because TAM, via unknown mechanisms, induces cognitive impairment in humans. A hallmark of cellular stress is...

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PMID: 26610346
DOI: 10.1186/s40478-015-0255-6
PMCID: PMC4660723

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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