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Article

CYP3A5 genotypes affect tacrolimus pharmacokinetics and infectious complications in Chinese pediatric liver transplant patients.

Pediatric transplantation - 1 Mar 2014

Xue Feng, Han Longzhi, Chen Yikuan, Xi Zhifeng, Li Qigen, Xu Ning, Xia Yun, Streicher Katie, Zhang Jianjun, Xia Qiang

Abstract excerpt

Little information is available regarding the impact of cytochrome P450 (CYP) 3A5 on the metabolism of TAC in infant LTx. Therefore, the CYP3A5 genotype of Chinese pediatric recipients (intestine) as well as donors (graft liver) was performed for the purpose of establishing an optimal dosage regimen in children. Sixty-four patients were divided according to CYP3A5 genotype (expression of *1 allele: EX and NEX)...

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Source

Identifiers

PMID: 24438215
DOI: 10.1111/petr.12216

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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