Iron-Overload–Related Disease in<i>HFE</i>Hereditary Hemochromatosis

Abstract excerpt

BACKGROUND: Most persons who are homozygous for C282Y, the HFE allele most commonly asssociated with hereditary hemochromatosis, have elevated levels of serum ferritin and transferrin saturation. Diseases related to iron overload develop in some C282Y homozygotes, but the extent of the risk is controversial. METHODS: We assessed HFE mutations in 31,192 persons of northern European descent between the ages of 40...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Hemoglobinopathies and Related Disorders
• Share to Iron Metabolism and Disorders
• Share to Vitamin K Research Studies