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Article

Equal parental origin of chromosome 22 losses in human sporadic meningioma: no evidence for genomic imprinting.

American journal of human genetics - 1 Nov 1990

Fontaine B, Rouleau G A, Seizinger B, Jewell A F, Hanson M P, Martuza R L, Gusella J F

Abstract excerpt

Inactivation of tumor suppressor genes can occur either by mutation at the gene locus or by loss of part or all of the chromosome region containing the gene. The latter is most frequently detected by DNA markers as loss of heterozygosity in the tumor tissue. In several reports, the paternal homologue was preferentially retained in embryonal tumors associated with loss of particular chromosomal regions, suggesting...

Topics

Alleles
Brain Neoplasms
Chromosomes, Human, Pair 22
DNA
Female
Genetic Markers
Genome, Human
Humans
Leukocytes
Male
Meningioma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Pedigree

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Identifiers

PMID: 2220822
PMCID: PMC1683679

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2220822-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Equal parental origin of chromosome 22 losses in human sporadic meningioma: no evidence for genomic imprinting.PMID 2220822Read ↗

Chromosomal deletions in anaplastic meningiomas suggest multiple regions outside chromosome 22 as important in tumor progressionSemantic proximity Read ↗

Deletion mapping of the long arm of chromosome 22 in human meningiomasSemantic proximity Read ↗

Chromosome 22 heterozygosity is retained in most hyperdiploid and pseudodiploid meningiomas.Semantic proximity Read ↗

Deletions on chromosome 22 in sporadic meningiomaSemantic proximity Read ↗

Loss of chromosome 22 alleles in human sporadic spinal schwannomas.Semantic proximity Read ↗

Allelic status of 1p, 14q, and 22q and NF2 gene mutations in sporadic schwannomas.Semantic proximity Read ↗

IGF2 but not H19 shows loss of imprinting in human glioma.Semantic proximity Read ↗

Interstitial loss and gain of sequences on chromosome 22 in meningiomas with normal karyotype.Semantic proximity Read ↗

Loss of chromosome 22 and absence of NF2 gene mutation in a case of multiple meningiomas.Semantic proximity Read ↗

Loss of heterozygosity for loci on chromosome 10 is associated with morphologically malignant meningioma progression.Semantic proximity Read ↗

Familial meningioma is not allelic to neurofibromatosis 2.Semantic proximity Read ↗

No evidence for the presence of an imprinted neuroblastoma suppressor gene within chromosome sub-band 1p36.3.Semantic proximity Read ↗

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