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Article

Loss of chromosome 22 alleles in human sporadic spinal schwannomas.

Annals of neurology - 1 Feb 1991

Fontaine B, Hanson M P, VonSattel J P, Martuza R L, Gusella J F

Abstract excerpt

Acoustic neuromas occur either as sporadic solitary tumors in the general population or as inherited bilateral tumors typically in patients with neurofibromatosis type 2. Loss of heterozygosity for markers on the long arm of chromosome 22 has been reported in both instances, and neurofibromatosis type 2 has been genetically linked to a marker on the long arm of this autosome, suggesting that a unique locus on...

Topics

Adult
Alleles
Blotting, Southern
Chromosomes, Human, Pair 22
DNA Probes
DNA, Neoplasm
Female
Heterozygote
Humans
Middle Aged
Neurilemmoma
Spinal Cord Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 2012386
DOI: 10.1002/ana.410290211

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2012386-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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