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Article

Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits.

The Journal of biological chemistry - 11 Feb 2005

Hill Kirsti, Krugmann Sonja, Andrews Simon R, Coadwell W John, Finan Peter, Welch Heidi C E, Hawkins Phillip T, Stephens Len R

Abstract excerpt

P-Rex1 is a guanine-nucleotide exchange factor (GEF) for the small GTPase Rac. We have investigated here the mechanisms of stimulation of P-Rex1 Rac-GEF activity by the lipid second messenger phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P3) and the Gbetagamma subunits of heterotrimeri...

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PMID: 15545267
DOI: 10.1074/jbc.M411262200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15545267-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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