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Article

Leukotriene B4 receptor locus gene characterisation and association studies in asthma.

BMC medical genetics - 20 Nov 2012

Tulah Asif S, Beghé Bianca, Barton Sheila J, Holloway John W, Sayers Ian

Abstract excerpt

BACKGROUND: Polymorphisms spanning genes involved in the production of leukotriene B4 (LTB4) e.g. ALOX5AP and LTA4H are associated with asthma susceptibility, suggesting a role for LTB4 in disease. The contribution of LTB4receptor polymorphism is currently unknown. The aim of this study was to characterise the genes for the two pivotal LTB4 receptors, LTB4R1 and LTB4R2 in lung tissue and determine if...

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PMID: 23167751
DOI: 10.1186/1471-2350-13-110
PMCID: PMC3607986

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