Article
Thrombocytopenia and erythrocytosis in mice with a mutation in the gene encoding the hemoglobin β minor chain.
Proceedings of the National Academy of Sciences of the United States of America - 10 Jan 2012
Kauppi Maria, Hilton Adrienne A, Metcalf Donald, Ng Ashley P, Hyland Craig D, Collinge Janelle E, Kile Benjamin T, Hilton Douglas J, Alexander Warren S
Abstract excerpt
Diverse mutations in the genes encoding hemoglobin (Hb) have been characterized in human disease. We describe here a mutation in the mouse Hbb-b2 gene, denoted Plt12, that precisely mimics the human hemoglobin Hotel Dieu variant. The mutation results in increased affinity of Hb for oxygen and Plt12 mutant mice exhibited reduced partial pressure of O(2) in the blood, accompanied by erythrocytosis characterized by...
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