Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A mouse model for beta 0-thalassemia.

5 Dec 1995

Abstract excerpt

We have used a "plug and socket" targeting technique to generate a mouse model of beta 0-thalassemia in which both the b1 and b2 adult globin genes have been deleted. Mice homozygous for this deletion (Hbbth-3/Hbbth-3) die perinatally, similar to the most severe form of Cooley anemia in humans. Mice heterozygous for the deletion appear normal, but their hematologic indices show characteristics typical of severe...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hemoglobinopathies and Related Disorders

Source

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Identifiers

PMID: 8524813
DOI: 10.1073/pnas.92.25.11608

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A mouse model for beta 0-thalassemia.PMID 8524813Read ↗

Preclinical transfusion-dependent humanized mouse model of beta thalassemia major.Semantic proximity Read ↗

A humanized mouse model for a common beta0-thalassemia mutation.Semantic proximity Read ↗

Knockout-Transgenic Mouse Model of Sickle Cell DiseaseSemantic proximity Read ↗

Mouse model of human beta zero thalassemia: targeted deletion of the mouse beta maj- and beta min-globin genes in embryonic stem cells.Semantic proximity Read ↗

A normal beta-globin allele as a modifier gene ameliorating the severity of alpha-thalassemia in mice.Semantic proximity Read ↗

Lessons from transgenic mouse lines expressing sickle hemoglobin.Semantic proximity Read ↗

A Common Human β Globin Splicing Mutation Modeled in MiceSemantic proximity Read ↗

Humanized beta-thalassemia mouse model containing the common IVSI-110 splicing mutation.Semantic proximity Read ↗

A mouse model for hemoglobin SC disease recapitulates characteristic human pathologies.Semantic proximity Read ↗

A humanized BAC transgenic/knockout mouse model for HbE/beta-thalassemia.Semantic proximity Read ↗

Transgenic mice and hemoglobinopathies.Semantic proximity Read ↗

CRISPR/Cas9-mediated β-globin gene knockout in rabbits recapitulates human β-thalassemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.