Article
Iron is a modifier of the phenotypes of JAK2-mutant myeloproliferative neoplasms.
Blood - 27 Apr 2023
Stetka Jan, Usart Marc, Kubovcakova Lucia, Rai Shivam, Rao Tata Nageswara, Sutter Joshua, Hao-Shen Hui, Dirnhofer Stefan, Geier Florian, Bader Michael S, Passweg Jakob R, Manolova Vania, Dürrenberger Franz, Ahmed Nouraiz, Schroeder Timm, Ganz Tomas, Nemeth Elizabeta, Silvestri Laura, Nai Antonella, Camaschella Clara, Skoda Radek C
Abstract excerpt
JAK 2-V617F mutation causes myeloproliferative neoplasms (MPNs) that can manifest as polycythemia vera (PV), essential thrombocythemia (ET), or primary myelofibrosis. At diagnosis, patients with PV already exhibited iron deficiency, whereas patients with ET had normal iron stores. We examined the influence of iron availability on MPN phenotype in mice expressing JAK2-V617F and in mice expressing JAK2 with an...
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