Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

JAK2 exon 12 mutant mice display isolated erythrocytosis and changes in iron metabolism favoring increased erythropoiesis.

Blood - 11 Aug 2016

Grisouard Jean, Li Sai, Kubovcakova Lucia, Rao Tata Nageswara, Meyer Sara C, Lundberg Pontus, Hao-Shen Hui, Romanet Vincent, Murakami Masato, Radimerski Thomas, Dirnhofer Stephan, Skoda Radek C

Abstract excerpt

Mutations in JAK2 exon 12 are frequently found in patients with polycythemia vera (PV) that do not carry a JAK2-V617F mutation. The majority of these patients display isolated erythrocytosis. We generated a mouse model that expresses JAK2-N542-E543del, the most frequent JAK2 exon 12 mutation found in PV patients. Mice expressing the human JAK2-N542-E543del (Ex12) showed a strong increase in red blood cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Erythrocytes
Share to Erythropoiesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Janus Kinase 2

Share to Mice, Inbred C57BL

Share to Mice, Transgenic

Share to Polycythemia

Source

Identifiers

PMID: 27288519
DOI: 10.1182/blood-2015-12-689216

Genes

JAK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

JAK2 exon 12 mutant mice display isolated erythrocytosis and changes in iron metabolism favoring increased erythropoiesis.PMID 27288519Read ↗

Iron is a modifier of the phenotypes of JAK2-mutant myeloproliferative neoplasms.Semantic proximity Read ↗

JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis.Semantic proximity Read ↗

The JAK2 exon 12 mutations: a comprehensive review.Semantic proximity Read ↗

Idiopathic erythrocytosis: a germline disease?Semantic proximity Read ↗

Distinct effects of V617F and exon12-mutated JAK2 expressions on erythropoiesis in a human induced pluripotent stem cell (iPSC)-based model.Semantic proximity Read ↗

Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera–like diseaseSemantic proximity Read ↗

Somatic mutations of JAK2 exon 12 in patients with JAK2 (V617F)-negative myeloproliferative disorders.Semantic proximity Read ↗

JAK2 V617F stimulates proliferation of erythropoietin-dependent erythroid progenitors and delays their differentiation by activating Stat1 and other nonerythroid signaling pathways.Semantic proximity Read ↗

Loss of Stat1 decreases megakaryopoiesis and favors erythropoiesis in a JAK2-V617F-driven mouse model of MPNs.Semantic proximity Read ↗

Distinct roles for long-term hematopoietic stem cells and erythroid precursor cells in a murine model of Jak2V617F-mediated polycythemia vera.Semantic proximity Read ↗

MPN patients with low mutant JAK2 allele burden show late expansion restricted to erythroid and megakaryocytic lineagesSemantic proximity Read ↗

Iron homeostasis governs erythroid phenotype in polycythemia vera.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.