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Article

A Mouse Model for Human Unstable Hemoglobin Santa Ana.

Comparative medicine - 1 Dec 2016

Miyashiro Samantha I, Massironi Silvia M G, Mori Claudia M C, Cruz Carolina C, Hagiwara Mitika K, Maiorka Paulo C

Abstract excerpt

In the present study, we described the phenotype, histologic morphology, and molecular etiology of a mouse model of unstable hemoglobin Santa Ana. Hematologic evaluation of anemic mice (Anem/+) discovered after N-ethyl-N-nitrosourea mutagenesis revealed moderate anemia with intense reticulocytosis and polychromasia, followed by anisocytosis, macrocytosis, hypochromia, and intraerythrocytic inclusion and Heinz...

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Identifiers

PMID: 28304246
PMCID: PMC5157958

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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