Article
A synonymous polymorphism of the Tristetraprolin (TTP) gene, an AU-rich mRNA-binding protein, affects translation efficiency and response to Herceptin treatment in breast cancer patients.
Human molecular genetics - 1 Dec 2011
Griseri Paola, Bourcier Christine, Hieblot Corinne, Essafi-Benkhadir Khadija, Chamorey Emmanuel, Touriol Christian, Pagès Gilles
Abstract excerpt
Post-transcriptional regulation plays a central role in cell differentiation and proliferation. Among the regulatory factors involved in this mechanism, Tristetraprolin (ZFP36 or TTP) is the prototype of a family of RNA-binding proteins that bind to adenylate and uridylate (AU)-rich sequences in the 3'UTR of mRNAs, which promotes their physiological decay. Here, we investigated whether TTP correlates with tumor...
Topics
- Angiogenesis Inducing Agents
- Antibodies, Monoclonal, Humanized
- Base Sequence
- Breast Neoplasms
- Case-Control Studies
- Cell Line, Tumor
- Cell Proliferation
- Clone Cells
- Female
- Gene Expression Regulation, Neoplastic
- HEK293 Cells
- Humans