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Article

Protein aggregates in Huntington's disease.

Experimental neurology - 1 Nov 2012

Arrasate Montserrat, Finkbeiner Steven

Abstract excerpt

Huntington's disease (HD) is an incurable neurodegenerative disease characterized by abnormal motor movements, personality changes, and early death. HD is caused by a mutation in the IT-15 gene that expands abnormally the number of CAG nucleotide repeats. As a result, the translated protein huntingtin contains disease-causing expansions of glutamines (polyQ) that make it prone to misfold and aggregate. While the...

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Identifiers

PMID: 22200539
DOI: 10.1016/j.expneurol.2011.12.013
PMCID: PMC3909772

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