Article
EGFR mutation up-regulates EGR1 expression through the ERK pathway.
Anticancer research - 1 Apr 2009
Maegawa Mari, Arao Tokuzo, Yokote Hideyuki, Matsumoto Kazuko, Kudo Kanae, Tanaka Kaoru, Kaneda Hiroyasu, Fujita Yoshihiko, Ito Fumiaki, Nishio Kazuto
Abstract excerpt
BACKGROUND: DelE746_A750-type EGFR is a constitutively active type of mutation that enhances EGFR signaling. However, the changes in gene expression that occur in mutant EGFR-harboring cells has not been fully studied. MATERIALS AND METHODS: A gene expression analysis of HEK293 cells transfected with wild-type or mutant EGFR was performed focusing on the significant gene. RESULTS: Early growth response 1 (EGR1),...
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