Reverse guanine phosphoribosyltransferase selection of recombinant vaccinia viruses.

doi:10.1016/0042-6822(90)90367-z

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Article

Reverse guanine phosphoribosyltransferase selection of recombinant vaccinia viruses.

Virology - 1 Oct 1990

Isaacs S N, Kotwal G J, Moss B

Abstract excerpt

We have developed a procedure for the selection of recombinant vaccinia viruses with applicability to poxvirus mutagenesis studies and to the use of vaccinia virus as an expression vector. The method depends on the specific inability of a recombinant vaccinia virus expressing the Escherichia coli...

Topics

Animals
Escherichia coli
Hypoxanthine Phosphoribosyltransferase
Mice
Mutation
Poxviridae
Recombination, Genetic
Tumor Cells, Cultured
Vaccinia virus
Viral Plaque Assay

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