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Article

Transient Host Range Selection for Genetic Engineering of Modified Vaccinia Virus Ankara

1 Jun 2000

Abstract excerpt

Recombinant vaccinia viruses are extremely valuable tools for research in molecular biology and immunology. The extension of vaccinia vector technology to replication-deficient and safety-tested virus strains such as modified vaccinia virus Ankara (MVA) have made this versatile eukaryotic expression system even more attractive for basic and clinical research. Here, we report on easily obtaining recombinant MVA...

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PMID: 10868279
DOI: 10.2144/00286st04

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Transient Host Range Selection for Genetic Engineering of Modified Vaccinia Virus AnkaraPMID 10868279Read ↗

Stable expression of the vaccinia virus K1L gene in rabbit cells complements the host range defect of a vaccinia virus mutant.Semantic proximity Read ↗

Vaccinia virus K1L protein supports viral replication in human and rabbit cells through a cell-type-specific set of its ankyrin repeat residues that are distinct from its binding site for ACAP2.Semantic proximity Read ↗

Attenuation and immunogenicity of host-range extended modified vaccinia virus Ankara recombinants.Semantic proximity Read ↗

Functional F11L and K1L genes in modified vaccinia virus Ankara restore virus-induced cell motility but not growth in human and murine cells.Semantic proximity Read ↗

Highly attenuated modified vaccinia virus Ankara replicates in baby hamster kidney cells, a potential host for virus propagation, but not in various human transformed and primary cells.Semantic proximity Read ↗

Vaccinia virus K1L protein mediates host-range function in RK-13 cells via ankyrin repeat and may interact with a cellular GTPase-activating protein.Semantic proximity Read ↗

A Novel Naturally Occurring Tandem Promoter in Modified Vaccinia Virus Ankara Drives Very Early Gene Expression and Potent Immune ResponsesSemantic proximity Read ↗

A PCR-based method for manipulation of the vaccinia virus genome that eliminates the need for cloning.Semantic proximity Read ↗

Introduction of the six major genomic deletions of modified vaccinia virus Ankara (MVA) into the parental vaccinia virus is not sufficient to reproduce an MVA-like phenotype in cell culture and in mice.Semantic proximity Read ↗

Recombination-Mediated Genetic Engineering of a Bacterial Artificial Chromosome Clone of Modified Vaccinia virus Ankara (MVA)Semantic proximity Read ↗

The orthopoxvirus 68-kilodalton ankyrin-like protein is essential for DNA replication and complete gene expression of modified vaccinia virus Ankara in nonpermissive human and murine cells.Semantic proximity Read ↗

Candidate influenza vaccines based on recombinant modified vaccinia virus AnkaraSemantic proximity Read ↗

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