Requirement of the NF-κB Subunit p65/RelA for K-Ras–Induced Lung Tumorigenesis

Abstract excerpt

K-Ras-induced lung cancer is a very common disease, for which there are currently no effective therapies. Because therapy directly targeting the activity of oncogenic Ras has been unsuccessful, a different approach for novel therapy design is to identify critical Ras downstream oncogenic targets. Given that oncogenic Ras proteins activate the transcription factor NF-kappaB, and the importance of NF-kappaB in...

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• Cell death mechanisms and regulation
• Cytokine Signaling Pathways and Interactions
• NF-κB Signaling Pathways