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Interferon Gamma in African Trypanosome Infections: Friends or Foes?

7 Sept 2017

Abstract excerpt

African trypanosomes cause fatal infections in both humans and livestock. Interferon gamma (IFN-γ) plays an essential role in resistance to African trypanosomes. However, increasing evidence suggests that IFN-γ, when excessively synthesized, also induces immunopathology, enhancing susceptibility to the infection. Thus, production of IFN-γ must be tightly regulated during infections with African trypanosomes to...

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PMID: 28936213
DOI: 10.3389/fimmu.2017.01105

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