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Article

Interleukin-1 receptor-associated kinase 4 is essential for initial host control of Brucella abortus infection.

Infection and immunity - 1 Nov 2011

Oliveira Fernanda S, Carvalho Natália B, Brandão Ana Paula M S, Gomes Marco Túlio R, de Almeida Leonardo A, Oliveira Sérgio C

Abstract excerpt

Brucella abortus is a facultative intracellular bacterial pathogen that causes abortion in domestic animals and undulant fever in humans. Recent studies have revealed that Toll-like receptor (TLR)-initiated immune response to Brucella spp. depends on myeloid differentiation factor 88 (MyD88) signaling. Therefore, we decided to study the role of the interleukin-1 receptor-associated kinase 4 (IRAK-4) in host...

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PMID: 21844234
DOI: 10.1128/IAI.05289-11
PMCID: PMC3257947

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