Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gamma interferon is not required for arthritis resistance in the murine Lyme disease model.

Infection and immunity - 1 Jun 2001

Glickstein L, Edelstein M, Dong J Z

Abstract excerpt

Lyme arthritis is the most common complication following infection of human individuals with Borrelia burgdorferi sensu stricto. In mice, B. burgdorferi infection leads to arthritis of the tibiotarsal joints. Arthritis severity in mice is under host genetic control, as BALB/c mice developed mild arthritis but C3H/He mice developed severe disease following B. burgdorferi infection. To study the role of gamma...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arthritis
Share to Borrelia burgdorferi Group
Share to Immunoglobulin G

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Interferon gamma Receptor

Share to Lyme Disease

Share to Mice, Inbred C3H

Share to Receptors, Interferon

Share to Th2 Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 11349038
DOI: 10.1128/IAI.69.6.3737-3743.2001
PMCID: PMC98381

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gamma interferon is not required for arthritis resistance in the murine Lyme disease model.PMID 11349038Read ↗

Experimental lyme arthritis in the absence of interleukin-4 or gamma interferon.Semantic proximity Read ↗

Gene Expression Profiling Reveals Unique Pathways Associated with Differential Severity of Lyme ArthritisSemantic proximity Read ↗

Altered proinflammatory cytokine production and enhanced resistance to Trypanosoma congolense infection in lymphotoxin beta-deficient mice.Semantic proximity Read ↗

T helper phenotype and genetic susceptibility in experimental Lyme disease.Semantic proximity Read ↗

MyD88 plays a unique role in host defense but not arthritis development in Lyme disease.Semantic proximity Read ↗

Ameliorated course of glucose-6-phosphate isomerase (G6PI)-induced arthritis in IFN-γ receptor knockout mice exposes an arthritis-promoting role of IFN-γ.Semantic proximity Read ↗

Genetic ablation of interferon-gamma up-regulates interleukin-1beta expression and enables the elicitation of collagen-induced arthritis in a nonsusceptible mouse strain.Semantic proximity Read ↗

The capacity to produce IFN-gamma rather than the presence of interleukin-4 determines the resistance and the degree of susceptibility to Leishmania donovani infection in mice.Semantic proximity Read ↗

Borrelia-primed and -infected mice deficient of interleukin-17 develop arthritis after neutralization of gamma-interferon.Semantic proximity Read ↗

Fas ligand deficiency impairs host inflammatory response against infection with the spirochete Borrelia burgdorferi.Semantic proximity Read ↗

Borrelia burgdorferi arthritis-associated locus Bbaa1 regulates Lyme arthritis and K/B×N serum transfer arthritis through intrinsic control of type I IFN production.Semantic proximity Read ↗

The Lyme Disease Spirochete<i>Borrelia burgdorferi</i>Utilizes Multiple Ligands, Including RNA, for Interferon Regulatory Factor 3-Dependent Induction of Type I Interferon-Responsive GenesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.