Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Humoral immunity and CD4+ Th1 cells are both necessary for a fully protective immune response upon secondary infection with Brucella melitensis.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2014

Vitry Marie-Alice, Hanot Mambres Delphine, De Trez Carl, Akira Shizuo, Ryffel Bernhard, Letesson Jean-Jacques, Muraille Eric

Abstract excerpt

Brucella spp are intracellular bacteria that cause brucellosis, one of the most common zoonoses in the world. Given the serious medical consequences of this disease, a safe and effective human vaccine is urgently needed. Efforts to develop this vaccine have been hampered by our lack of understanding of what constitutes a protective memory response against Brucella. In this study, we characterize the cells and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacteremia
Share to Brucella melitensis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Brucellosis

Share to H-2 Antigens

Share to Immunity, Humoral

Share to Interleukin-12

Share to Myeloid Differentiation Factor 88

Share to Vaccines, Inactivated

Source

Identifiers

PMID: 24646742
DOI: 10.4049/jimmunol.1302561

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Humoral immunity and CD4+ Th1 cells are both necessary for a fully protective immune response upon secondary infection with Brucella melitensis.PMID 24646742Read ↗

Targeting resident memory T cell immunity culminates in pulmonary and systemic protection against Brucella infection.Semantic proximity Read ↗

Translating innate immunity into immunological memory: implications for vaccine development.Semantic proximity Read ↗

Protection conferred by intraperitoneal Group A <i>Streptococcus</i> immunization relies on macrophages and IFN-γ but not on concurrent adaptive immune responsesSemantic proximity Read ↗

Secondary CD8+ T-cell responses are controlled by systemic inflammation.Semantic proximity Read ↗

Immune Mediators Important for a Protective Recall Response to <em>Babesia microti</em>Semantic proximity Read ↗

Infection-induced trained immunity: a twist in paradigm of innate host defense and generation of immunological memorySemantic proximity Read ↗

Protective capacity of memory CD8+ T cells is dictated by antigen exposure history and nature of the infection.Semantic proximity Read ↗

Trained immunity and host‐pathogen interactionsSemantic proximity Read ↗

Th17 Cells Are the Dominant T Cell Subtype Primed by Shigella flexneri Mediating Protective ImmunitySemantic proximity Read ↗

IFN-γ–Induced Priming Maintains Long-Term Strain-Transcending Immunity against Blood-Stage Plasmodium chabaudi MalariaSemantic proximity Read ↗

Vaccination with a ΔnorD ΔznuA Brucella abortus mutant confers potent protection against virulent challenge.Semantic proximity Read ↗

Systemic BCG immunization induces persistent lung mucosal multifunctional CD4 T(EM) cells which expand following virulent mycobacterial challenge.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.