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Article

Sequestering of Rac by the Yersinia effector YopO blocks Fcgamma receptor-mediated phagocytosis.

The Journal of biological chemistry - 5 Feb 2010

Groves Eleanor, Rittinger Katrin, Amstutz Marlise, Berry Sara, Holden David W, Cornelis Guy R, Caron Emmanuelle

Abstract excerpt

Pathogenic Yersinia species neutralize innate immune mechanisms by injecting type three secretion effectors into immune cells, altering cell signaling. Our study elucidates how one of these effectors, YopO, blocks phagocytosis. We demonstrate using different phagocytic models that YopO specifical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19926792
DOI: 10.1074/jbc.M109.071035
PMCID: PMC2823549

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19926792-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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