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Article

Rab27a is a key component of the secretory machinery of azurophilic granules in granulocytes.

The Biochemical journal - 1 Mar 2007

Munafó Daniela B, Johnson Jennifer L, Ellis Beverly A, Rutschmann Sophie, Beutler Bruce, Catz Sergio D

Abstract excerpt

Neutrophils kill micro-organisms using microbicidal products that they release into the phagosome or into the extracellular space. The secretory machinery utilized by neutrophils is poorly characterized. We show that the small GTPase Rab27a is an essential component of the secretory machinery of azurophilic granules in granulocytes. Rab27a-deficient mice have impaired secretion of MPO (myeloperoxidase) into the...

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Share to Exocytosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17090228
DOI: 10.1042/BJ20060950
PMCID: PMC1798439

Genes

MPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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