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Article

Mismatch repair, but not heteroduplex rejection, is temporally coupled to DNA replication.

Science (New York, N.Y.) - 23 Dec 2011

Hombauer Hans, Srivatsan Anjana, Putnam Christopher D, Kolodner Richard D

Abstract excerpt

In eukaryotes, it is unknown whether mismatch repair (MMR) is temporally coupled to DNA replication and how strand-specific MMR is directed. We fused Saccharomyces cerevisiae MSH6 with cyclins to restrict the availability of the Msh2-Msh6 mismatch recognition complex to either S phase or G2/M phase of the cell cycle. The Msh6-S cyclin fusion was proficient for suppressing mutations at three loci that replicate at...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22194578
DOI: 10.1126/science.1210770
PMCID: PMC3806717

Genes

MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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