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Article

Direct coupling between meiotic DNA replication and recombination initiation.

Science (New York, N.Y.) - 27 Oct 2000

Borde V, Goldman A S, Lichten M

Abstract excerpt

During meiosis in Saccharomyces cerevisiae, DNA replication occurs 1. 5 to 2 hours before recombination initiates by DNA double-strand break formation. We show that replication and recombination initiation are directly linked. Blocking meiotic replication prevented double-strand break formation in a replication-checkpoint-independent manner, and delaying replication of a chromosome segment specifically delayed...

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Source

Identifiers

PMID: 11052944
DOI: 10.1126/science.290.5492.806

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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