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Article

Tau's role in the developing brain: implications for intellectual disability

21 Dec 2011

Abstract excerpt

Microdeletions encompassing the MAPT (Tau) locus resulting in intellectual disability raised the hypothesis that Tau may regulate early functions in the developing brain. Our results indicate that neuronal migration was inhibited in mouse brains following Tau reduction. In addition, the leading edge of radially migrating neurons was aberrant in spite of normal morphology of radial glia. Furthermore, intracellular...

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PMID: 22194194
DOI: 10.1093/hmg/ddr603

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