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Article

High-resolution temporal and regional mapping of MAPT expression and splicing in human brain development

10 Apr 2018

Abstract excerpt

The microtubule associated protein tau plays a critical role in the pathogenesis of neurodegenerative disease. Recent studies suggest that tau also plays a role in disorders of neuronal connectivity, including epilepsy and post-traumatic stress disorder. Animal studies have shown that the MAPT gene, which codes for the tau protein, undergoes complex pre-mRNA alternative splicing to produce multiple isoforms...

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PMID: 29634760
DOI: 10.1371/journal.pone.0195771

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