Article
Disruption of the MAP1B-related protein FUTSCH leads to changes in the neuronal cytoskeleton, axonal transport defects, and progressive neurodegeneration in Drosophila.
Molecular biology of the cell - 1 May 2005
Bettencourt da Cruz Alexandre, Schwärzel Martin, Schulze Sabine, Niyyati Mahtab, Heisenberg Martin, Kretzschmar Doris
Abstract excerpt
The elaboration of neuronal axons and dendrites is dependent on a functional cytoskeleton. Cytoskeletal components have been shown to play a major role in the maintenance of the nervous system through adulthood, and changes in neurofilaments and microtubule-associated proteins (MAPs) have been linked to a variety of neurodegenerative diseases. Here we show that Futsch, the fly homolog of MAP1B, is involved in...
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