Article
TUBB5 and its disease-associated mutations influence the terminal differentiation and dendritic spine densities of cerebral cortical neurons.
Human molecular genetics - 1 Oct 2014
Ngo Linh, Haas Matilda, Qu Zhengdong, Li Shan Shan, Zenker Jennifer, Teng Kathleen Sue Lyn, Gunnersen Jenny Margaret, Breuss Martin, Habgood Mark, Keays David Anthony, Heng Julian Ik-Tsen
Abstract excerpt
The microtubule cytoskeleton is critical for the generation and maturation of neurons in the developing mammalian nervous system. We have previously shown that mutations in the β-tubulin gene TUBB5 cause microcephaly with structural brain abnormalities in humans. While it is known that TUBB5 is necessary for the proper generation and migration of neurons, little is understood of the role it plays in neuronal...
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