Article
Aquaporin-4 promotes memory consolidation in Morris water maze.
Brain structure & function - 1 Jan 2013
Fan Yi, Liu Mengdi, Wu Xin, Wang Fang, Ding Jianhua, Chen Jianguo, Hu Gang
Abstract excerpt
Aquaporin-4 (AQP4), the most abundant aquaporin in the brain, is polarized at the glial end-feet facing peri-synaptic areas. AQP4 has been hypothesized to modulate water and potassium fluxes associated with neuronal activity in pathophysiological states. However, the role of AQP4 in astroglial signaling under physiological conditions is unclear. Herein, AQP4 knockout mice and wild-type littermates were tested in...
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