Article
Astrocytic water channel aquaporin-4 modulates brain plasticity in both mice and humans: a potential gliogenetic mechanism underlying language-associated learning.
Molecular psychiatry - 1 Apr 2018
Woo J, Kim J E, Im J J, Lee J, Jeong H S, Park S, Jung S-Y, An H, Yoon S, Lim S M, Lee S, Ma J, Shin E Y, Han Y-E, Kim B, Lee E H, Feng L, Chun H, Yoon B-E, Kang I, Dager S R, Lyoo I K, Lee C J
Abstract excerpt
The role of astrocytes in brain plasticity has not been extensively studied compared with that of neurons. Here we adopted integrative translational and reverse-translational approaches to explore the role of an astrocyte-specific major water channel in the brain, aquaporin-4 (AQP4), in brain plasticity and learning. We initially identified the most prevalent genetic variant of AQP4 (single nucleotide...
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