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Article

High-intensity interval training ameliorates Alzheimer's disease-like pathology by regulating astrocyte phenotype-associated AQP4 polarization.

Theranostics - 1 Jan 2023

Feng Shu, Wu Chongyun, Zou Peibin, Deng Qianting, Chen Zhe, Li Meng, Zhu Ling, Li Fanghui, Liu Timon Cheng-Yi, Duan Rui, Yang Luodan

Abstract excerpt

Background: Alzheimer's disease (AD), one of the most common forms of dementia, is a widely studied neurodegenerative disease characterized by Aβ accumulation and tau hyperphosphorylation. Currently, there is no effective cure available for AD. The astrocyte AQP4 polarized distribution-mediated glymphatic system is essential for Aβ and abnormal tau clearance and is a potential therapeutic target for AD. However,...

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Identifiers

PMID: 37351177
DOI: 10.7150/thno.81951
PMCID: PMC10283053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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