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Article

Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb.

Genes & development - 15 Aug 2003

Soshnikova Natalia, Zechner Dietmar, Huelsken Joerg, Mishina Yuji, Behringer Richard R, Taketo Makoto M, Crenshaw E Bryan, Birchmeier Walter

Abstract excerpt

By conditional gene ablation in mice, we found that beta-catenin, an essential downstream effector of canonical Wnt signaling, is a key regulator of formation of the apical ectodermal ridge (AER) and of the dorsal-ventral axis of the limbs. By generation of compound mutants, we also show that beta-catenin acts downstream of the BMP receptor IA in AER induction, but upstream or parallel in dorsal-ventral...

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Identifiers

PMID: 12923052
DOI: 10.1101/gad.263003
PMCID: PMC196251

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Source receipt: pubmed, retrieved 7 Sept 2026.

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