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Article

High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1).

Pharmacogenetics - 1 Jul 2004

Niemi Mikko, Schaeffeler Elke, Lang Thomas, Fromm Martin F, Neuvonen Mikko, Kyrklund Carl, Backman Janne T, Kerb Reinhold, Schwab Matthias, Neuvonen Pertti J, Eichelbaum Michel, Kivistö Kari T

Abstract excerpt

This study aimed to characterize possible relationships between polymorphisms in the drug transporter genes organic anion transporting polypeptide-C (OATP-C, SLCO1B1), OATP-B (SLCO2B1), multidrug resistance-associated protein 2 (MRP2, ABCC2) and multidrug resistance transporter (MDR1, ABCB1) and the pharmacokinetics of pravastatin. We studied 41 healthy Caucasian volunteers who had previously participated in...

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Source

Identifiers

PMID: 15226675
DOI: 10.1097/01.fpc.0000114750.08559.32

Genes

ABCB1
ABCC2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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