Inactivation of arf-bp1 induces p53 activation and diabetic phenotypes in mice.

Abstract excerpt

It is well accepted that the Mdm2 ubiquitin ligase acts as a major factor in controlling p53 stability and activity in vivo. Although several E3 ligases have been reported to be involved in Mdm2-independent p53 degradation, the roles of these ligases in p53 regulation in vivo remain largely unknown. To elucidate the physiological role of the ubiquitin ligase ARF-BP1, we generated arf-bp1 mutant mice. We found...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Aging
• Share to Diabetes Mellitus
• Share to Homeostasis