Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prolonged mammosphere culture of MCF-7 cells induces an EMT and repression of the estrogen receptor by microRNAs.

Breast cancer research and treatment - 1 Feb 2012

Guttilla I K, Phoenix K N, Hong X, Tirnauer J S, Claffey K P, White B A

Abstract excerpt

Mammosphere culture has been used widely for the enrichment of mammary epithelial stem cells and breast cancer stem cells (CSCs). Epithelial-to-mesenchymal transition (EMT) also induces stem cell features in normal and transformed mammary cells. We examined whether mammosphere culture conditions per se induced EMT in the epithelial MCF-7 breast cancer cell line. MCF-7 cells were cultured as mammospheres for 5...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Culture Techniques
Share to Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Estrogen Receptor alpha

Share to Mice, SCID

Share to Neoplasm Transplantation

Share to Neoplastic Stem Cells

Share to Spheroids, Cellular

Share to Tumor Burden

Source

Identifiers

PMID: 21553120
DOI: 10.1007/s10549-011-1534-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prolonged mammosphere culture of MCF-7 cells induces an EMT and repression of the estrogen receptor by microRNAs.PMID 21553120Read ↗

Characterization of the stemness potency of mammospheres isolated from the breast cancer cell linesSemantic proximity Read ↗

Mammosphere Formation in Breast Carcinoma Cell Lines Depends upon Expression of E-cadherinSemantic proximity Read ↗

Comparison of mammosphere formation from breast cancer cell lines and primary breast tumors.Semantic proximity Read ↗

Isolation, Culture, and Differentiation of Mammary Epithelial Stem/Progenitor Cells from Fresh or Ex Vivo Cultured Human Breast TissueSemantic proximity Read ↗

Re-expression of miR-21 contributes to migration and invasion by inducing epithelial-mesenchymal transition consistent with cancer stem cell characteristics in MCF-7 cells.Semantic proximity Read ↗

Mammosphere cells from high-passage MCF7 cell line show variable loss of tumorigenicity and radioresistance.Semantic proximity Read ↗

Phenotypic characterization of mammosphere-forming cells from the human MA-11 breast carcinoma cell line.Semantic proximity Read ↗

Mesenchymal traits are selected along with stem features in breast cancer cells grown as mammospheres.Semantic proximity Read ↗

Estrogen promotes reversible epithelial-to-mesenchymal-like transition and collective motility in MCF-7 breast cancer cells.Semantic proximity Read ↗

Let-7: A regulator of the ERα signaling pathway in human breast tumors and breast cancer stem cellsSemantic proximity Read ↗

Mammosphere‐derived gene set predicts outcome in patients with ER‐positive breast cancerSemantic proximity Read ↗

Tamoxifen selects for breast cancer cells with mammosphere forming capacity and increased growth rate.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.