Article
High frequency of complex TP53 mutations in CNS metastases from breast cancer.
British journal of cancer - 17 Jan 2012
Lo Nigro C, Vivenza D, Monteverde M, Lattanzio L, Gojis O, Garrone O, Comino A, Merlano M, Quinlan P R, Syed N, Purdie C A, Thompson A, Palmieri C, Crook T
Abstract excerpt
BACKGROUND: Brain metastasis from breast cancer is usually associated with a poor prognosis and early death. Alteration of p53 may contribute to malignant progression by abrogation of apoptosis induced by oncogene activation and by acquisition of gain-of-function properties, which promote tumour aggression. Mutation in TP53 occurs at high frequency in carcinomas of the lung and gastro-intestinal tract, but is...
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