Article
Risk of metastasis in BRCA2 carriers diagnosed with triple-negative breast cancer.
Cancer medicine - 1 Aug 2023
Moreno Marcelo, Oliveira Júlia Salles, Brianese Rafael Canfield, de Castro Douglas Guedes, Sanches Solange Moraes, Torrezan Giovana Tardin, Santiago Karina Miranda, De Brot Marina, Cordeiro de Lima Vladmir Claudio, Baroni Alves Makdissi Fabiana, Casali Da Rocha Jose Claudio, Calsavara Vinicius Fernando, Carraro Dirce Maria
Abstract excerpt
BACKGROUND: Triple-negative breast cancer (TNBC) is the neoplasia most associated with BRCA1 germline pathogenic variants (PV) and is more likely to develop metastases than the other breast cancer (BC) subtypes, mainly in the lungs and the central nervous system (CNS). Recently, BRCA2 carriers were shown to have a higher risk for developing CNS metastases. However, the patterns of recurrence and metastases of...
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