Article
Discordance of PIK3CA and TP53 mutations between breast cancer brain metastases and matched primary tumors.
Scientific reports - 7 Dec 2021
Thulin Anna, Andersson Carola, Werner Rönnerman Elisabeth, De Lara Shahin, Chamalidou Chaido, Schoenfeld Arnd, Kovács Anikó, Fagman Henrik, Enlund Fredrik, Linderholm Barbro K
Abstract excerpt
There is limited knowledge of the biology of breast cancer (BC) brain metastasis (BM). We primarily aimed to determine the mutations in BCBM and to compare the mutational pattern with the matched primary breast cancer (BC). Secondary aims were to determine mutations in each subgroup (Luminal A-/B-like, HER2+ and TNBC) of BCBM, and to determine survival according to specific mutations. We investigated 57 BCBMs,...
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