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Article

Engineering a synthetic cell panel to identify signalling components reprogrammed by the cell growth regulator anterior gradient-2.

Molecular bioSystems - 1 Jun 2014

Gray Terry A, Alsamman Khaldoon, Murray Euan, Sims Andrew H, Hupp Ted R

Abstract excerpt

AGR2 forms an ER-resident signalling axis in cell development, limb regeneration, and in human diseases like asthma and cancer, yet molecular mechanisms underlying its effects remain largely undefined. A single integrated Flippase recombination target (FRT) site was engineered within the AGR2-non expressing A375 cell line to allow integration of a constitutively expressed AGR2 alleles. This allows an analysis of...

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Source

Identifiers

PMID: 24710632
DOI: 10.1039/c4mb00113c

Genes

AGR2
AGR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Engineering a synthetic cell panel to identify signalling components reprogrammed by the cell growth regulator anterior gradient-2.PMID 24710632Read ↗

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