TP 53 and MDM2 gene polymorphisms and risk of hepatocellular carcinoma among Italian patients

Abstract excerpt

BACKGROUND: Single-nucleotide polymorphisms within TP53 gene (codon 72 exon 4, rs1042522, encoding either arginine or proline) and MDM2 promoter (SNP309; rs2279744), have been independently associated with increased risk of several cancer types. Few studies have analysed the role of these polymorphisms in the development of hepatocellular carcinoma. METHODS: Genotype distribution of TP53 codon 72 and MDM2 SNP309...

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