Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tudor domain ERI-5 tethers an RNA-dependent RNA polymerase to DCR-1 to potentiate endo-RNAi.

Nature structural & molecular biology - 18 Dec 2011

Thivierge Caroline, Makil Neetha, Flamand Mathieu, Vasale Jessica J, Mello Craig C, Wohlschlegel James, Conte Darryl, Duchaine Thomas F

Abstract excerpt

Endogenous RNA interference (endo-RNAi) pathways use a variety of mechanisms to generate siRNA and to mediate gene silencing. In Caenorhabditis elegans, DCR-1 is essential for competing RNAi pathways-the ERI endo-RNAi pathway and the exogenous RNAi pathway-to function. Here, we demonstrate that DCR-1 forms exclusive complexes in each pathway and further define the ERI-DCR-1 complex. We show that the tandem tudor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Embryo, Nonmammalian

Share to Immunoprecipitation

Share to Ribonuclease III

Share to RNA-Dependent RNA Polymerase

Share to RNA-Induced Silencing Complex

Share to RNA, Small Interfering

Source

Open in PubMed Open full text

Identifiers

PMID: 22179787
DOI: 10.1038/nsmb.2186
PMCID: PMC3684169

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tudor domain ERI-5 tethers an RNA-dependent RNA polymerase to DCR-1 to potentiate endo-RNAi.PMID 22179787Read ↗

Interacting endogenous and exogenous RNAi pathways in Caenorhabditis elegans.Semantic proximity Read ↗

A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans.Semantic proximity Read ↗

Dual roles of EGO-1 and RRF-1 in regulating germline exo-RNAi efficiency in <i>Caenorhabditis elegans</i>Semantic proximity Read ↗

EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans.Semantic proximity Read ↗

The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications.Semantic proximity Read ↗

Antisense transcription licenses nascent transcripts to mediate transcriptional gene silencing.Semantic proximity Read ↗

Biogenesis of mature piRNAs in <i>Caenorhabditis elegans</i> is dependent on orchestration between multiple ribonucleases and PRG-1Semantic proximity Read ↗

Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7.Semantic proximity Read ↗

Germ granule compartments coordinate specialized small RNA productionSemantic proximity Read ↗

Characterizing the role of RSD-6 in the biogenesis of virus-derived small interfering RNAs and the modulation of viral pathogenesisSemantic proximity Read ↗

The CSR-1 endogenous RNAi pathway ensures accurate transcriptional reprogramming during the oocyte-to-embryo transition in Caenorhabditis elegans.Semantic proximity Read ↗

Distinct phases of siRNA synthesis in an endogenous RNAi pathway in C. elegans soma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.