Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thyroid hormone receptors TRalpha1 and TRbeta differentially regulate gene expression of Kcnq4 and prestin during final differentiation of outer hair cells.

Journal of cell science - 15 Jul 2006

Winter Harald, Braig Claudia, Zimmermann Ulrike, Geisler Hyun-Soon, Fränzer Jürgen-Theodor, Weber Thomas, Ley Matthias, Engel Jutta, Knirsch Martina, Bauer Karl, Christ Stephanie, Walsh Edward J, McGee JoAnn, Köpschall Iris, Rohbock Karin, Knipper Marlies

Abstract excerpt

Thyroid hormone (TH or T3) and TH-receptor beta (TRbeta) have been reported to be relevant for cochlear development and hearing function. Mutations in the TRbeta gene result in deafness associated with resistance to TH syndrome. The effect of TRalpha1 on neither hearing function nor cochlear T3 target genes has been described to date. It is also uncertain whether TRalpha1 and TRbeta can act simultaneously on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anion Transport Proteins
Share to Hair Cells, Auditory, Outer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypothyroidism

Share to KCNQ Potassium Channels

Share to Sulfate Transporters

Share to Thyroid Hormone Receptors alpha

Share to Thyroid Hormone Receptors beta

Share to Thyroid Hormones

Source

Identifiers

PMID: 16803873
DOI: 10.1242/jcs.03013

Genes

KCNQ4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thyroid hormone receptors TRalpha1 and TRbeta differentially regulate gene expression of Kcnq4 and prestin during final differentiation of outer hair cells.PMID 16803873Read ↗

Retardation of cochlear maturation and impaired hair cell function caused by deletion of all known thyroid hormone receptors.Semantic proximity Read ↗

Autonomous functions of murine thyroid hormone receptor TRα and TRβ in cochlear hair cells.Semantic proximity Read ↗

Deafness in TRbeta mutants is caused by malformation of the tectorial membrane.Semantic proximity Read ↗

A disease-associated mutation in thyroid hormone receptor α1 causes hearing loss and sensory hair cell patterning defects in mice.Semantic proximity Read ↗

Complete activation of thyroid hormone receptor β by T3 is essential for normal cochlear function and morphology in mice.Semantic proximity Read ↗

Deafness and loss of cochlear hair cells in the absence of thyroid hormone transporters Slc16a2 (Mct8) and Slc16a10 (Mct10).Semantic proximity Read ↗

The thyroid hormone receptor beta gene: structure and functions in the brain and sensory systems.Semantic proximity Read ↗

THOC1 deficiency leads to late-onset nonsyndromic hearing loss through p53-mediated hair cell apoptosisSemantic proximity Read ↗

Thyroid hormone receptor beta is essential for development of auditory function.Semantic proximity Read ↗

THOC1 deficiency leads to late-onset nonsyndromic hearing loss through p53-mediated hair cell apoptosis.Semantic proximity Read ↗

Suppression of the deafness and thyroid dysfunction in Thrb-null mice by an independent mutation in the Thra thyroid hormone receptor alpha gene.Semantic proximity Read ↗

Apoptosis in acquired and genetic hearing impairment: the programmed death of the hair cell.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.